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Article

Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization.

Nature communications - 22 Sept 2021

Sharma Rajesh, Choi Kyoung-Jae, Quan My Diem, Sharma Sonum, Sankaran Banumathi, Park Hyekyung, LaGrone Anel, Kim Jean J, MacKenzie Kevin R, Ferreon Allan Chris M, Kim Choel, Ferreon Josephine C

Abstract excerpt

Expression of a few master transcription factors can reprogram the epigenetic landscape and three-dimensional chromatin topology of differentiated cells and achieve pluripotency. During reprogramming, thousands of long-range chromatin contacts are altered, and changes in promoter association with enhancers dramatically influence transcription. Molecular participants at these sites have been identified, but how...

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Identifiers

PMID: 34552088
DOI: 10.1038/s41467-021-25761-7
PMCID: PMC8458463

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