Article
The evolution of hematopoietic cells under cancer therapy
2020-10-29
Abstract excerpt
Chemotherapies may influence the evolution of somatic tissues through the introduction of genetic variation in cells and by changing the selective pressures they face. However, the contributions of chemotherapeutic agents to the mutation burden of healthy cells and to clonal expansions in somatic tissues are not clear. Here, we exploit the mutational footprint of some chemotherapies to explore their influence on t...
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Identifiers and source
- Literature Corpus work
- 61eb6244-6719-5b9a-b8e1-c28da9a9e8a7
- DOI
- 10.1101/2020.10.29.360230