Distinct landscape and clinical implications of therapy-related clonal hematopoiesis.

Abstract excerpt

Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in individuals previously treated with chemotherapy and/or radiation therapy. With the increased use of genetic analysis in oncological care, the detection of t-CH among cancer patients is becoming increasingly common. t-CH arises through the selective bottleneck imposed by chemotherapies and potentially through direct...

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• Clonal Hematopoiesis
• Checkpoint Kinase 2
• CHEK2 gene
• Mutation
• Neoplasm Proteins