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Article

The evolution of hematopoietic cells under cancer therapy.

Nature communications - 10 Aug 2021

Pich Oriol, Cortes-Bullich Albert, Muiños Ferran, Pratcorona Marta, Gonzalez-Perez Abel, Lopez-Bigas Nuria

Abstract excerpt

Chemotherapies may increase mutagenesis of healthy cells and change the selective pressures in tissues, thus influencing their evolution. However, their contributions to the mutation burden and clonal expansions of healthy somatic tissues are not clear. Here, exploiting the mutational footprint of some chemotherapies, we explore their influence on the evolution of hematopoietic cells. Cells of Acute Myeloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34376657
DOI: 10.1038/s41467-021-24858-3
PMCID: PMC8355079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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