Article

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

2024-05-24

Abstract excerpt

Normal hematopoietic stem and progenitor cells (HSPCs) inherently accumulate somatic mutations and lose clonal diversity with age, processes implicated in the development of myeloid malignancies 1 . The impact of exogenous stressors, such as cancer chemotherapies, on the genomic integrity and clonal dynamics of normal HSPCs is not well defined. We conducted whole-genome sequencing on 1,032 single-cell-derived HSP...

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Literature Corpus work: 41c0370a-6f93-536e-ace1-af5c0e9589a1
DOI: 10.1101/2024.05.23.595594

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