Article
Mutagenic Impact and Evolutionary Influence of Chemoradiotherapy in Hematologic Malignancies.
Blood cancer discovery - 3 Sept 2025
Diamond Benjamin, Chahar Dhanvantri, Jain Michael D, Poos Alexandra M, Durante Michael A, Ziccheddu Bachisio, Kaddoura Marcella, Papadimitriou Marios, Maclachlan Kylee H, Jelinek Tomas, Davies Faith E, Figura Nicholas B, Morgan Gareth J, Mai Elias K, Weisel Katja, Fenk Roland, Raab Marc S, Usmani Saad, Landgren Ola, Locke Frederick L, Goldschmidt Hartmut, Schatz Jonathan Harry, Weinhold Niels, Maura Francesco
Abstract excerpt
Ionizing radiotherapy (RT) is a widely used treatment strategy for malignancies. In solid tumors, RT-induced double-strand breaks lead to the accumulation of insertion-deletions (indels; ID), and their repair by nonhomologous end joining has been linked to the ID8 mutational signature in surviving cells. However, the extent of RT-induced mutagenesis in hematologic malignancies and its impact on their mutational...
Read the complete abstract on PubMedTopics
- Humans
- Hematologic Neoplasms
- Chemoradiotherapy
- Mutagenesis