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The long-term effects of chemotherapy on normal blood cells

1 Jul 2025

Abstract excerpt

Several chemotherapeutic agents act by increasing DNA damage in cancer cells, triggering cell death. However, there is limited understanding of the extent and long-term consequences of collateral DNA damage in normal tissues. To investigate the impact of chemotherapy on mutation burdens and the cell population structure of normal tissue, we sequenced blood cell genomes from 23 individuals aged 3-80 years who were...

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PMID: 40596443
DOI: 10.1038/s41588-025-02234-x

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