Article
Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms.
Cancer discovery - 5 Aug 2022
Bertrums Eline J M, Rosendahl Huber Axel K M, de Kanter Jurrian K, Brandsma Arianne M, van Leeuwen Anaïs J C N, Verheul Mark, van den Heuvel-Eibrink Marry M, Oka Rurika, van Roosmalen Markus J, de Groot-Kruseman Hester A, Zwaan C Michel, Goemans Bianca F, van Boxtel Ruben
Abstract excerpt
Childhood cancer survivors are confronted with various chronic health conditions like therapy-related malignancies. However, it is unclear how exposure to chemotherapy contributes to the mutation burden and clonal composition of healthy tissues early in life. Here, we studied mutation accumulation in hematopoietic stem and progenitor cells (HSPC) before and after cancer treatment of 24 children. Of these...
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