Article
Oncologic therapy shapes the fitness landscape of clonal hematopoiesis
2019-11-20
Abstract excerpt
<h4>ABSTRACT</h4> Clonal hematopoiesis (CH) is frequent in cancer patients and associated with increased risk of therapy related myeloid neoplasms (tMN). To define the relationship between CH, oncologic therapy, and tMN progression, we studied 24,439 cancer patients. We show that previously treated patients have increased rates of CH, with enrichment of mutations in DNA Damage Response (DDR) genes ( TP53, PPM1D,...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 33630349-dddd-555f-84ea-9bcf021c03e2
- DOI
- 10.1101/848739