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Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation

1 Jul 2025

Abstract excerpt

The impact of exogenous stressors, such as cancer chemotherapies, on the genomic integrity and clonal dynamics of normal hematopoiesis is not well defined. We conducted whole-genome sequencing on 1,276 single-cell-derived hematopoietic stem and progenitor cell (HSPC) colonies from ten patients with multiple myeloma treated with chemotherapies and six normal donors. Melphalan treatment significantly increased the...

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PMID: 40596442
DOI: 10.1038/s41588-025-02235-w

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