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The Microglial <i>Trem2</i> R47H Alzheimer’s Disease Risk Variant Does Not Detectably Alter Hippocampal Synaptic Transmission in Young Mice

2025-08-22

Abstract excerpt

<h4>Summary</h4> The rare R47H variant of the microglial TREM2 gene increases Alzheimer’s disease (AD) risk, but its effects on early hippocampal circuitry remain unclear. Trem2 has been reported to be important for microglial-dependent refinement of excitatory synaptic circuits in development. We hypothesized that loss of TREM2 function might result in changes in circuitry due to reduced microglial ability to...

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Literature Corpus work
61b7f798-ab86-5fd9-a151-a94bc75bff26
DOI
10.1101/2025.08.22.671714
Open publication

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The Microglial <i>Trem2</i> R47H Alzheimer’s Disease Risk Variant Does Not Detectably Alter Hippocampal Synaptic Transmission in Young MiceDOI 10.1101/2025.08.22.671714
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