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Article

iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss.

Glia - 1 Feb 2024

Penney Jay, Ralvenius William T, Loon Anjanet, Cerit Oyku, Dileep Vishnu, Milo Blerta, Pao Ping-Chieh, Woolf Hannah, Tsai Li-Huei

Abstract excerpt

Genetic findings have highlighted key roles for microglia in the pathology of neurodegenerative conditions such as Alzheimer's disease (AD). A number of mutations in the microglial protein triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for developing AD, most notably the R47H/+ substitution. We employed gene editing and stem cell models to gain insight into the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37969043
DOI: 10.1002/glia.24485
PMCID: PMC10904109

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