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Article

Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.

Neurobiology of disease - 1 Oct 2023

Das Melanie, Mao Wenjie, Voskobiynyk Yuliya, Necula Deanna, Lew Irene, Petersen Cathrine, Zahn Allie, Yu Gui-Qiu, Yu Xinxing, Smith Nicholas, Sayed Faten A, Gan Li, Paz Jeanne T, Mucke Lennart

Abstract excerpt

The R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2) increases the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed knockin mice expressing human TREM2-R47H from one mutant mouse Trem2 allele. TREM2-R47H mice showed increased seizure activity in response to an acute excitotoxin challenge, compared to wildtype controls or knockin mice expressing the common...

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Identifiers

PMID: 37591465
DOI: 10.1016/j.nbd.2023.106263
PMCID: PMC10681293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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