Article

High-throughput siRNA screening reveals functional interactions and redundancies of human processive exoribonucleases

2020-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Processive exoribonucleases, the executors of RNA decay, participate in multiple physical and functional interactions. Unlike physical ones, functional relationships have not been investigated in human cells. Here we have screened cells deficient in DIS3, XRN2, EXOSC10, DIS3L, and DIS3L2 with a custom siRNA library and determined their functional interactions with diverse pathways of RNA metabol...

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Literature Corpus work: 61859aab-ce03-5a30-8a15-2feaffcb8289
DOI: 10.1101/2020.08.05.238006

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