Article

Identification of Human Pathways Acting on Nuclear Non-Coding RNAs Using the Mirror Forward Genetic Approach

2024-09-27

Abstract excerpt

<h4>SUMMARY</h4> Despite critical roles in diseases, human pathways acting on strictly nuclear non-coding RNAs have been refractory to forward genetics. To enable their forward genetic discovery, we developed a single-cell approach that “Mirrors” activities of nuclear pathways with cytoplasmic fluorescence. Application of Mirror to two nuclear pathways targeting MALAT1’s 3′ end, the pathway of its maturation and...

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Literature Corpus work: 8d3e8f67-2397-50af-8c68-25e6ced2750c
DOI: 10.1101/2024.09.26.615073

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