Article

Multiple Quality Control Checkpoints Safeguard Small Nuclear RNA Biogenesis and Prevent Assembly of Aberrant Spliceosomes

2025-11-23

Abstract excerpt

<h4>Summary</h4> Defective small nuclear (sn)RNAs are produced from hundreds of human snRNA pseudogenes and mutant snRNA genes associated with human developmental disorders. Machineries that prevent defective snRNAs from disrupting pre-mRNA splicing remain poorly defined. Here, we identify multiple checkpoints in snRNA biogenesis monitored by quality control machineries that subject defective snRNAs to degradatio...

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Literature Corpus work: 4a2f9092-b95d-53bc-9c00-aea947f6f77d
DOI: 10.1101/2025.11.21.689835

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