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Article

The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease

17 Jul 2015

Abstract excerpt

DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3' to 5' degradation and processing of both nuclear and cytoplasmic RNA species. Recently, aberrant expression of DIS3 has been found to be implicated in a range of different cancers. Perhaps most striking is the finding that DIS3 is recurrently mutated in 11% of multiple myeloma patients. Much work has...

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PMID: 26193331
DOI: 10.3390/biom5031515

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The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human DiseasePMID 26193331Read ↗

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The roles of the exoribonucleases DIS3L2 and XRN1 in human diseaseSemantic proximity Read ↗

A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias.Semantic proximity Read ↗

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The multiple lives of DEAD-box RNA helicase DP103/DDX20/Gemin3Semantic proximity Read ↗

Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolismSemantic proximity Read ↗

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