Article

EXOSC10-mediated pre-tRNA surveillance safeguards neuron survival

2025-06-19

Abstract excerpt

<h4>ABSTRACT</h4> tRNA quality control pathways have been identified in yeast, whereby aberrant and hypomodified mature tRNAs are targeted for 5’-3’ degradation by the rapid tRNA decay (RTD) pathway involving the Xrn1 and Rat1/Xrn2 exonucleases, whereas aberrant precursor tRNAs (pre-tRNAs) are targeted for 3’-5’ degradation by the nuclear surveillance pathway involving the RNA Exosome. However, the pathways contr...

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Literature Corpus work: 2787a4a1-eedc-512a-bd6e-1110fce1b010
DOI: 10.1101/2025.06.19.660564

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