Article
Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target.
Nucleic acids research - 1 Jan 2014
Tomecki Rafal, Drazkowska Karolina, Kucinski Iwo, Stodus Krystian, Szczesny Roman J, Gruchota Jakub, Owczarek Ewelina P, Kalisiak Katarzyna, Dziembowski Andrzej
Abstract excerpt
hDIS3 is a mainly nuclear, catalytic subunit of the human exosome complex, containing exonucleolytic (RNB) and endonucleolytic (PIN) active domains. Mutations in hDIS3 have been found in ∼10% of patients with multiple myeloma (MM). Here, we show that these mutations interfere with hDIS3 exonucleolytic activity. Yeast harboring corresponding mutations in DIS3 show growth inhibition and changes in nuclear RNA...
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