Article

Clonally heritable gene expression imparts a layer of diversity within cell types

2022-02-16

Abstract excerpt

Cell types can be classified based on shared patterns of transcription. Variability in gene expression between individual cells of the same type has been ascribed to stochastic transcriptional bursting and transient cell states. We asked whether long-term, heritable differences in transcription can impart diversity within a cell type. Studying clonal human lymphocytes and mouse brain cells, we uncover a vast diver...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7cdfb6bb-b6a1-51e9-8427-377854529915
DOI: 10.1101/2022.02.14.480352

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clonally heritable gene expression imparts a layer of diversity within cell typesDOI 10.1101/2022.02.14.480352Read

Transcriptional heterogeneity predicts and enables clonal selection in ageing haematopoiesisSemantic proximity Read

Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq.Semantic proximity Read

Extent, heritability, and functional relevance of single cell expression variability in highly homogeneous populations of human cellsSemantic proximity Read

Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.Semantic proximity Read

Epigenetic fluctuations underlie gene expression timescales and variability.Semantic proximity Read

Epigenetic gene expression noise and phenotypic diversification of clonal cell populations.Semantic proximity Read

Beyond the mean: genetic control of gene expression fidelity and dispersionSemantic proximity Read

Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability.Semantic proximity Read

Non-genetic heterogeneity--a mutation-independent driving force for the somatic evolution of tumours.Semantic proximity Read

Diversity training for signal transduction: leveraging cell-to-cell variability to dissect cellular signaling, differentiation and death.Semantic proximity Read

Monoallelic Gene Expression: Stochastic or Clonal? From Detection to Mechanisms and Clinical Significance.Semantic proximity Read

Variation is function: Are single cell differences functionally important?: Testing the hypothesis that single cell variation is required for aggregate function.Semantic proximity Read