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Clonal Hematopoiesis Dynamics and Evolutionary Fitness During Cancer Treatment Impact Clinical Outcomes

2025-09-02

Abstract excerpt

Clonal hematopoiesis (CH) is the age-related expansion of mutated hematopoietic stem cells without other hematologic abnormalities. In patients with solid tumors, CH is associated with higher mortality and may evolve to therapy-related myeloid neoplasms; however, the mechanisms by which cancer treatments promote CH dynamics remain largely unknown. Here, we analyzed 392 serial samples from a prospective cohort of b...

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Literature Corpus work
614a9450-eea5-535b-a079-9e038cea74e6
DOI
10.1101/2025.08.27.25334581
Open publication

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Clonal Hematopoiesis Dynamics and Evolutionary Fitness During Cancer Treatment Impact Clinical OutcomesDOI 10.1101/2025.08.27.25334581
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