Article
Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications.
International journal of laboratory hematology - 1 Oct 2026
Du Wei, Koga Shunsuke, Yang Guang, Gill Saar, Bagg Adam
Abstract excerpt
Clonal hematopoiesis (CH) is increasingly recognized as a significant biological phenomenon in aging and cancer, marked by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations in genes associated with myeloid neoplasms. While CH is strongly linked to a spectrum of inflammatory diseases and hematologic malignancies, its role in shaping responses to cancer immunotherapy-especially...
Read the complete abstract on PubMedTopics
- Humans
- Clonal Hematopoiesis
- Immunotherapy, Adoptive
- Hematologic Neoplasms
- T-Lymphocytes
- Receptors, Chimeric Antigen
