Article
Clonal hematopoiesis in older patients with breast cancer receiving chemotherapy.
Journal of the National Cancer Institute - 8 Aug 2023
Mayerhofer Christina, Sedrak Mina S, Hopkins Judith O, Li Tianyu, Tayob Nabihah, Faggen Meredith G, Sinclair Natalie F, Chen Wendy Y, Parsons Heather A, Mayer Erica L, Lange Paulina B, Basta Ameer S, Perilla-Glen Adriana, Lederman Ruth I, Wong Andrew R, Tiwari Abhay, McAllister Sandra S, Mittendorf Elizabeth A, Gibson Christopher J, Burstein Harold J, Kim Annette S, Freedman Rachel A, Miller Peter G
Abstract excerpt
BACKGROUND: The expansion of hematopoietic stem cells carrying recurrent somatic mutations, termed clonal hematopoiesis (CH), is common in elderly individuals and is associated with increased risk of myeloid malignancy and all-cause mortality. Though chemotherapy is a known risk factor for developing CH, how myelosuppressive therapies affect the short-term dynamics of CH remains incompletely understood. Most...
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