Article
Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes.
The Journal of clinical investigation - 15 Jul 2026
Arabzadeh Mona, Tang Yi-Han, Colin-Leitzinger Christelle, Marzban Sadegh, Walgenbach Daniel, Morganti Stefania, Mahaganapathy Vaidhyanathan, Harper Erika, Teng Mingxiang, Kresovich Jacob K, Washington Iman, Parsons Heather A, Garber Judy E, West Jeffrey, Ganesan Shridar, Khiabanian Hossein, Gillis Nancy
Abstract excerpt
Clonal hematopoiesis (CH) is the age-related expansion of mutated hematopoietic stem cells without hematologic abnormalities. In patients with solid tumors, CH is associated with higher mortality and may evolve to therapy-related myeloid neoplasms; however, the mechanisms by which cancer treatments promote CH dynamics remain largely unknown. Here, we analyzed 392 serial samples from a prospective cohort of...
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