Article

Cell type-Specific <i>In Vivo</i> Proteomes with a Multi-copy Mutant Methionyl t-RNA Synthetase Mouse Line

2024-12-02

Abstract excerpt

The functional diversity of cells is driven by the different proteins they express. While improvements in protein labeling techniques have allowed for the measurement of proteomes with increased sensitivity, measuring cell type-specific proteomes in vivo remains challenging. One of the most useful pipelines is bioorthogonal non-canonical amino acid tagging (BONCAT) with the MetRS* system, consisting of a transgen...

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Literature Corpus work: 61417350-995f-5d50-8d1c-15b743bb1975
DOI: 10.1101/2024.11.28.625838

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