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Article

Cell type-specific in vivo proteomes with a multicopy mutant methionyl tRNA synthetase mouse line.

Lab animal - 1 Sept 2025

Alvarez-Pardo Rodrigo, Tom Dieck Susanne, Desch Kristina, Nassim Assir Belquis, Olmedo Salinas Cristina, Sivakumar Riya S, Langer Julian D, Schuman Erin M, Alvarez-Castelao Beatriz

Abstract excerpt

The functional diversity of cells is driven by the different proteins they express. While improvements in protein labeling techniques have enabled the measurement of proteomes with increased sensitivity, measuring cell type-specific proteomes in vivo remains challenging. One of the most useful pipelines is bio-orthogonal noncanonical amino acid tagging (BONCAT) with the MetRS* system, consisting of a transgenic...

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PMID: 40804162
DOI: 10.1038/s41684-025-01589-2
PMCID: PMC12404990

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