Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Noncanonical amino acids in the interrogation of cellular protein synthesis.

Accounts of chemical research - 20 Sept 2011

Ngo John T, Tirrell David A

Abstract excerpt

Proteins in living cells can be made receptive to bioorthogonal chemistries through metabolic labeling with appropriately designed noncanonical amino acids (ncAAs). In the simplest approach to metabolic labeling, an amino acid analog replaces one of the natural amino acids specified by the protein's gene (or genes) of interest. Through manipulation of experimental conditions, the extent of the replacement can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkynes
Share to Amino Acyl-tRNA Synthetases
Share to Azides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catalysis

Share to Copper

Share to Fluorescent Dyes

Share to Glycine

Share to Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 21815659
DOI: 10.1021/ar200144y
PMCID: PMC3178009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Noncanonical amino acids in the interrogation of cellular protein synthesis.PMID 21815659Read ↗

Cell-selective metabolic labeling of proteins.Semantic proximity Read ↗

Identification of secreted bacterial proteins by noncanonical amino acid tagging.Semantic proximity Read ↗

Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics.Semantic proximity Read ↗

Cell-specific proteomic analysis in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic code expansion in mammalian cellsSemantic proximity Read ↗

Incorporation of non-canonical amino acids into proteins in yeast.Semantic proximity Read ↗

Cell-selective labelling of proteomes in Drosophila melanogaster.Semantic proximity Read ↗

Cell type-specific in vivo proteomes with a multicopy mutant methionyl tRNA synthetase mouse line.Semantic proximity Read ↗

Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells.Semantic proximity Read ↗

Genetic Code Expansion Tools to Study Lysine AcylationSemantic proximity Read ↗

Enhanced yield of recombinant proteins with site-specifically incorporated unnatural amino acids using a cell-free expression system.Semantic proximity Read ↗

Cell type-Specific <i>In Vivo</i> Proteomes with a Multi-copy Mutant Methionyl t-RNA Synthetase Mouse LineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.