Article
A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele.
BMC medical genetics - 25 Apr 2008
Haasl Ryan J, Ahmadi M Reza, Meethal Sivan Vadakkadath, Gleason Carey E, Johnson Sterling C, Asthana Sanjay, Bowen Richard L, Atwood Craig S
Abstract excerpt
Genetic and biochemical studies support the apolipoprotein E (APOE) epsilon4 allele as a major risk factor for late-onset Alzheimer's disease (AD), though ~50% of AD patients do not carry the allele. APOE transports cholesterol for luteinizing hormone (LH)-regulated steroidogenesis, and both LH and neurosteroids have been implicated in the etiology of AD. Since polymorphisms of LH beta-subunit (LHB) and its...
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