Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Genetic Relevance of Human Induced Pluripotent Stem Cell-Derived Microglia to Alzheimer’s Disease and Major Neuropsychiatric Disorders

1 Jan 2019

Abstract excerpt

Microglia are the primary innate immune cell type in the brain that have been implicated in the pathogenesis of several neurodegenerative and neuropsychiatric disorders, most notably Alzheimer's disease (AD) and schizophrenia. Microglia generated from human induced pluripotent stem cells (hiPSCs) represent a promising in vitro cellular model for studying the neuroimmune interactions involved in these disorders....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32399472
DOI: 10.1159/000501935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Genetic Relevance of Human Induced Pluripotent Stem Cell-Derived Microglia to Alzheimer’s Disease and Major Neuropsychiatric DisordersPMID 32399472Read ↗

Using Stems to Bear Fruit: Deciphering the Role of Alzheimer’s Disease Risk Loci in Human-Induced Pluripotent Stem Cell-Derived MicrogliaSemantic proximity Read ↗

Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer’s DiseaseSemantic proximity Read ↗

Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegenerationSemantic proximity Read ↗

An integrated toolkit for human microglia functional genomicsSemantic proximity Read ↗

Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.Semantic proximity Read ↗

Functional Mature Human Microglia Developed in Human iPSC Microglial Chimeric Mouse BrainSemantic proximity Read ↗

Comparing the potential of microglia preparations generated using different human iPSC-based differentiation methods to model microglia-mediated mechanisms of amyotrophic lateral sclerosis pathophysiologySemantic proximity Read ↗

Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain.Semantic proximity Read ↗

An Integrated Neuroimmune Assembloid Model to Advance Neurodegenerative Disease StudiesSemantic proximity Read ↗

New Human IPSC Models of Late-onset Alzheimer’s Disease Polygenic Risk Identify Multiple Impairments of Microglial FunctionSemantic proximity Read ↗

A resource for generating and manipulating human microglial states in vitroSemantic proximity Read ↗

Integration of iPSC-derived microglia into human midbrain organoids enhances microglial maturation and inflammatory signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.