Article

GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma

2022-05-02

Abstract excerpt

<h4>Background</h4> Aggressive primary brain tumors such as glioblastoma are uniquely challenging to treat. The intracranial location poses barriers to therapy, and the potential for severe toxicity. Effective treatments for primary brain tumors are limited, and 5-year survival rates remain poor. Immune checkpoint inhibitor therapy has transformed treatment of some other cancers but has yet to significantly benef...

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Literature Corpus work: 609f1cf6-9f17-5cf8-a365-498f1c8688bc
DOI: 10.1101/2022.05.01.490250

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