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Article

Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment.

Journal of cancer research and clinical oncology - 28 Feb 2026

Cakmak Pinar, Lun Jennifer H, Köhler Miriam, Burger Michael C, Macas Jadranka, Starzetz Tatjana, Schulz Marcel H, Reiss Yvonne, Plate Karl H, Weber Katharina J

Abstract excerpt

PURPOSE: Glioblastoma, IDH-wildtype is a highly aggressive and often recurrent brain malignancy characterized by a profoundly immunosuppressive and heterogeneous tumor microenvironment. In this study, we aimed to systematically compare commonly used immune profiling methodologies. METHODS: We conducted a cross-platform comparison using matched primary and recurrent tumor samples analyzed by immunohistochemistry,...

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Identifiers

PMID: 41762316
DOI: 10.1007/s00432-026-06428-6
PMCID: PMC12950149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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