Article

A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion

2025-04-25

Abstract excerpt

<title>Abstract</title> <p>Tumor-infiltrating lymphocyte (TIL) therapy, recently approved by the FDA for melanoma, is an emerging modality for cell-based immunotherapy. However, its application in immunologically “cold” tumors such as glioblastoma remains limited due to sparse T cell infiltration, antigenic heterogeneity, and a suppressive tumor microenvironment. To identify genomic and spatial determinants of TI...

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Literature Corpus work: dd18d99c-badb-5f04-9564-9060347b1c4f
DOI: 10.21203/rs.3.rs-6314842/v1

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