Article

A novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> While chimeric antigen receptor (CAR) T cells have achieved encouraging remission rates in hematological malignancies, they demonstrated limited success in treating Glioblastoma (GBM), particularly due to high intra- and intertumoral heterogeneity. In this study, we identified a relevant and preserved target antigen, Podoplanin (PDPN), and evaluated the potential of a PDPN-...

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Literature Corpus work: 87d16412-ec07-5e29-9404-8634bb3bab38
DOI: 10.1101/2025.02.03.636223

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