Tumor-infiltrating CD8+ sub-populations in primary and recurrent glioblastoma: An in-silico study

Abstract excerpt

Background Glioblastoma multiforme (GBM) remains an incurable primary brain tumor. CD8 + tumor-infiltrating lymphocytes (TILs) can target malignant cells; however, their anti-tumoral immune responses mostly do not lead to GBM rejection in GBM patients. We profiled the sub-populations of tumor-infiltrating CD8 + T-cells, i.e., naïve, cytotoxic, and exhausted cells, in primary and recurrent GBM tissues and provided...