Article

Autologous Anti-GD2 CAR T Cells Efficiently Target Primary Human Glioblastoma

2023-10-26

Abstract excerpt

Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes, potentially compromising the development of autologous CAR T cell therapies. We here generated pre-clinical investigations of autologous anti-GD2 CAR T cells tested against 2D and 3D models of GBM primary cells. We detected a robust anti-tumor effect, highlighting th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2aa883e8-064b-5bc6-8843-32e2abdc64ad
DOI: 10.21203/rs.3.rs-2586023/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Autologous Anti-GD2 CAR T Cells Efficiently Target Primary Human GlioblastomaDOI 10.21203/rs.3.rs-2586023/v1Read

GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastomaSemantic proximity Read

HER2-targeting CAR-T cells show highly efficient anti-tumor activity against glioblastoma both in vitro and in vivoSemantic proximity Read

HER2-targeting CAR-T cells show highly efficient anti-tumor activity against glioblastoma both in vitro and in vivoSemantic proximity Read

NKG2D-Based CAR T Cells and Radiotherapy Exert Synergistic Efficacy in GlioblastomaSemantic proximity Read

Humanized glioblastoma patient-derived orthotopic xenografts recreate a locally immunosuppressed human immune ecosystem amenable to immunotherapeutic modulationSemantic proximity Read

Adoptive transfer of IL13Rα2-specific T cells for the treatment of glioblastoma: building on clinical achievements with second-generation CARsSemantic proximity Read

Allogeneic CAR T Cells: An Alternative to Overcome Challenges of CAR T Cell Therapy in GlioblastomaSemantic proximity Read

CAR T cell therapy for glioblastoma: A review of the first decade of clinical trialsSemantic proximity Read

7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomasSemantic proximity Read

A Bi-Specific T Cell-Engaging Antibody Triggers Protective Immune Memory and Glioma Microenvironment Remodeling in Immune Competent Preclinical ModelsSemantic proximity Read

Gene Targets of CAR-T Cell Therapy for GlioblastomaSemantic proximity Read

Technical advancement in regulatory T cell isolation and characterization using CD127 expression in patients with malignant glioma treated with autologous dendritic cell vaccinationSemantic proximity Read