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<i>OCT1</i> Variants Are Associated with Metformin Clearance and Gluconeogenesis: Mechanistic Insights for Youth-Onset Type 2 Diabetes in the MIGHTY Study

2026-05-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Aims/Hypothesis</h4> Behavioral and phenotypic characteristics do not fully explain variability in African Americans with youth-onset type 2 diabetes (Y-T2D) treated with metformin with or without liraglutide. We hypothesized that biological heterogeneity, including genetic variation in the metformin transporter OCT1, influences metformin pharmacokinetics and hepatic glucose flux. Therefor...

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Literature Corpus work
6092df62-4a08-5f00-980d-d7a592cd30bf
DOI
10.64898/2026.05.27.26354152
Open publication

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<i>OCT1</i> Variants Are Associated with Metformin Clearance and Gluconeogenesis: Mechanistic Insights for Youth-Onset Type 2 Diabetes in the MIGHTY StudyDOI 10.64898/2026.05.27.26354152
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