Article

Long-Term Efficacy and Safety of GLP-1R Agonist and SGLT2 Inhibitor Therapy in the General Population: A 2x2 Factorial Mendelian Randomization Study

2025-07-16

Abstract excerpt

<h4>Introduction</h4> Sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor (GLP-1R) agonists reduce the risk of major adverse cardiovascular and kidney events in individuals with various cardiometabolic conditions. The long-term efficacy and safety of these therapies, especially in low- and moderate-risk populations, remain uncertain. <h4>Methods</h4> We conducted a biobank-scal...

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Literature Corpus work: d491e8a0-15a1-57bf-b547-d7e15aad1f5b
DOI: 10.1101/2025.07.15.25331531

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