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Article

The variant organic cation transporter 2 (OCT2)-T201M contribute to changes in insulin resistance in patients with type 2 diabetes treated with metformin.

Diabetes research and clinical practice - 1 Apr 2015

Kashi Zahra, Masoumi Parisa, Mahrooz Abdolkarim, Hashemi-Soteh Mohammad Bagher, Bahar Adele, Alizadeh Ahad

Abstract excerpt

AIMS: Insulin resistance is characterized by impaired biological response of peripheral tissues to the metabolic effects of insulin. Organic cation transporter 2 (OCT2) is responsible for 80% metformin clearance. Limited information is available on the potential relationship between genetic variants of OCT2 and insulin resistance. In this study, we examined the role of OCT2-T201M (602 C>T) variant in insulin...

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Source

Identifiers

PMID: 25662675
DOI: 10.1016/j.diabres.2015.01.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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