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Virus-driven tRNA competition universally represses host genes with similar codon usage

2026-07-06

Abstract excerpt

Viral infection induces tRNA competition between viral and host genes, often repressing host translation. However, how endogenous genes are affected by this competition remains unclear. Three possible hypotheses are considered: abundant-tRNA shortage, rare-tRNA shortage, and viral similarity repression. Pan-virus Ribo-seq data show that endogenous genes with codon usage bias (CUB) matching host tRNA supply or vira...

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Literature Corpus work
6031c15e-ec37-5f53-bb07-e1f7ace5af80
DOI
10.64898/2026.07.02.736060
Open publication

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Virus-driven tRNA competition universally represses host genes with similar codon usageDOI 10.64898/2026.07.02.736060
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