Article
A slight mismatch between a gene's codon usage and the cellular tRNA supply is beneficial.
Nature communications - 17 Feb 2026
Chen Feng, Liu Yao, Zhou Ziwei, Liao Jia, Fan Xinran, Huang Yanying, Chen Yifei, Chen Jingyu, Yang Jian-Rong
Abstract excerpt
Each amino acid except two is encoded by multiple synonymous codons, but at unequal frequencies. Such codon usage bias (CUB) is observable in almost all species, and commonly assumed as the result of natural selection towards an optimal CUB that matches the cellular tRNA supply. Here we hypothesize instead that the optimal CUB of a gene should slightly mismatch the tRNA supply to avoid excessive translational...
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