Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for selection on SARS-CoV-2 RNA translation revealed by the evolutionary dynamics of mutations in UTRs and CDSs.

RNA biology - 1 Jan 2022

Zhu Lin, Wang Qi, Zhang Weiyu, Hu Hao, Xu Kexin

Abstract excerpt

RNA translation is the rate-limiting step when cells synthesize proteins. Elevating translation efficiency (TE) is intuitively beneficial. Particularly, when viruses invade host cells, how to compete with endogenous RNAs for efficient translation is a major issue to be resolved. We collected millions of worldwide SARS-CoV-2 sequences during the past year and traced the dynamics of allele frequency of every...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Codon, Initiator
Share to COVID-19

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Mutation

Share to RNA, Viral

Share to SARS-CoV-2

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 35762570
DOI: 10.1080/15476286.2022.2092351
PMCID: PMC9584556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for selection on SARS-CoV-2 RNA translation revealed by the evolutionary dynamics of mutations in UTRs and CDSs.PMID 35762570Read ↗

SARS-CoV-2 competes with host mRNAs for efficient translation by maintaining the mutations favorable for translation initiation.Semantic proximity Read ↗

Host-dependent C-to-U RNA editing in SARS-CoV-2 creates novel viral genes with optimized expressibility.Semantic proximity Read ↗

SARS-CoV-2 Displays a Suboptimal Codon Usage Bias for Efficient Translation in Human Cells Diverted by Hijacking the tRNA EpitranscriptomeSemantic proximity Read ↗

Large-scale analysis of SARS-CoV-2 synonymous mutations reveals the adaptation to the human codon usage during the virus evolutionSemantic proximity Read ↗

Analysis of 3.5 million SARS-CoV-2 sequences reveals unique mutational trends with consistent nucleotide and codon frequencies.Semantic proximity Read ↗

Temporal evolution and adaptation of SARS-CoV-2 codon usageSemantic proximity Read ↗

From SARS and MERS CoVs to SARS‐CoV‐2: Moving toward more biased codon usage in viral structural and nonstructural genesSemantic proximity Read ↗

Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemicSemantic proximity Read ↗

Betacoronaviruses genome analysis reveals evolution toward specific codons usage: Implications for SARS-CoV-2 mitigation strategies.Semantic proximity Read ↗

SARS-CoV-2 has the advantage of competing the iMet-tRNAs with human hosts to allow efficient translation.Semantic proximity Read ↗

SARS-CoV-2 mutations altering regulatory properties: deciphering host’s and virus’s perspectivesSemantic proximity Read ↗

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.