Synonymous Virus Genome Recoding as a Tool to Impact Viral Fitness.

doi:10.1016/j.tim.2015.11.002

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Article

Synonymous Virus Genome Recoding as a Tool to Impact Viral Fitness.

Trends in microbiology - 1 Feb 2016

Martínez Miguel Angel, Jordan-Paiz Ana, Franco Sandra, Nevot Maria

Abstract excerpt

Synthetic genome recoding is a novel method of generating viruses with altered phenotypes, whereby many synonymous mutations are introduced into the protein coding region of the virus genome without altering the encoded proteins. Virus genome recoding with large numbers of slightly deleterious mutations has produced attenuated forms of several RNA viruses. Virus genome recoding can also aid in investigating virus...

Topics

Animals
Genome, Viral
Humans
Mutation
Virus Diseases
Virus Physiological Phenomena
Viruses

Source

Open in PubMed

Identifiers

PMID: 26646373
DOI: 10.1016/j.tim.2015.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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