Article

Essentiality and dynamic expression of the human tRNA pool during viral infection

2024-04-30

Abstract excerpt

Human viruses depend on the translation resources of the host cell. A significant translation resource is the tRNA pool of the cell, as human viruses do not encode tRNA genes. Through tRNA sequencing, we inspected the human tRNA pool upon infection of human Cytomegalovirus (HCMV) and SARS-CoV-2. HCMV-induced alterations in tRNA expression were predominantly virus-driven, with minimal influence from the cellular im...

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Literature Corpus work: 384376bc-f67b-5bcb-bdad-327f93e32fbc
DOI: 10.1101/2024.04.25.591047

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