Article
Effect of correlated tRNA abundances on translation errors and evolution of codon usage bias.
PLoS genetics - 16 Sept 2010
Shah Premal, Gilchrist Michael A
Abstract excerpt
Despite the fact that tRNA abundances are thought to play a major role in determining translation error rates, their distribution across the genetic code and the resulting implications have received little attention. In general, studies of codon usage bias (CUB) assume that codons with higher tRNA abundance have lower missense error rates. Using a model of protein translation based on tRNA competition and...
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