Article
The amino acid substitution affects cellular response to mistranslation
2021-05-15
Abstract excerpt
<h4>ABSTRACT</h4> Mistranslation, the mis-incorporation of an amino acid not specified by the “standard” genetic code, occurs in all organisms. tRNA variants that increase mistranslation arise spontaneously and engineered tRNAs can achieve mistranslation frequencies approaching 10% in yeast and bacteria. Interestingly, human genomes contain tRNA variants with the potential to mistranslate. Cells cope with increas...
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Identifiers and source
- Literature Corpus work
- 6021a219-9ca2-5d8c-a7ac-07542a14dc3f
- DOI
- 10.1101/2021.05.12.443880