Serine mistranslation induces the integrated stress response through the P stalk.

Abstract excerpt

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that support robust and accurate protein synthesis. A rapidly expanding number of studies show that mutations in aaRSs lead to multiple human diseases, including neurological disorders and cancer. How aaRS mutations impact human health is not fully understood. In particular, our knowledge of how aminoacylation errors affect stress responses and fitness in...

Topics

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• Amino Acyl-tRNA Synthetases
• Mutation
• Protein Biosynthesis
• Ribosomes
• RNA, Transfer
• Serine