Article
Visualizing tRNA-dependent mistranslation in human cells.
RNA biology - 1 Jan 2018
Lant Jeremy T, Berg Matthew D, Sze Daniel H W, Hoffman Kyle S, Akinpelu Ibukunoluwa C, Turk Matthew A, Heinemann Ilka U, Duennwald Martin L, Brandl Christopher J, O'Donoghue Patrick
Abstract excerpt
High-fidelity translation and a strictly accurate proteome were originally assumed as essential to life and cellular viability. Yet recent studies in bacteria and eukaryotic model organisms suggest that proteome-wide mistranslation can provide selective advantages and is tolerated in the cell at higher levels than previously thought (one error in 6.9 × 10-4 in yeast) with a limited impact on phenotype....
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