Article
Mistranslation of the genetic code by a new family of bacterial transfer RNAs.
The Journal of biological chemistry - 1 Jul 2023
Schuntermann Dominik B, Fischer Jonathan T, Bile Jonmatthew, Gaier Sarah A, Shelley Brett A, Awawdeh Aya, Jahn Martina, Hoffman Kyle S, Westhof Eric, Söll Dieter, Clarke Christopher R, Vargas-Rodriguez Oscar
Abstract excerpt
The correct coupling of amino acids with transfer RNAs (tRNAs) is vital for translating genetic information into functional proteins. Errors during this process lead to mistranslation, where a codon is translated using the wrong amino acid. While unregulated and prolonged mistranslation is often toxic, growing evidence suggests that organisms, from bacteria to humans, can induce and use mistranslation as a...
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