Article

Serine mistranslation induces the integrated stress response without accumulation of uncharged tRNAs

2024-02-08

Abstract excerpt

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that support robust and accurate protein synthesis. A rapidly expanding number of studies show that mutations in aaRSs lead to multiple human diseases, including neurological disorders and cancer. Much remains unknown about how aaRS mutations impact human health. In particular, how aminoacylation errors affect stress responses and fitness in eukaryotic cells...

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Literature Corpus work: faae157a-a85b-5349-9850-6ad024352f87
DOI: 10.1101/2024.02.04.578812

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