Article

Targeted Cleavage and Polyadenylation of RNA by CRISPR-Cas13

2019-01-26

Abstract excerpt

Post-transcriptional cleavage and polyadenylation of messenger and long noncoding RNAs is coordinated by a supercomplex of ~20 individual proteins within the eukaryotic nucleus 1,2 . Polyadenylation plays an essential role in controlling RNA transcript stability, nuclear export, and translation efficiency 3–6 . More than half of all human RNA transcripts contain multiple polyadenylation signal sequences that can...

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Literature Corpus work: 600297b7-025b-547b-b4ef-f9c2b807dc98
DOI: 10.1101/531111

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